ABSTRACT:

This study aimed to evaluate the risk of oxidative stress by potassium bromate (KBrO3) and protective effect of aqueous extract of Moringa oleifera leaf in the spleen as a result of changes in some lipid profiles, antioxidant and marker enzymes. Twenty rats were divided into 4 groups with Group I animals as control given normal feed with water while Groups II, III and IV were administered with 1.0mL of potassium bromate solution (30 mg/kg body weight) while in addition 1.0mL of 20% and 40% aqueous extract of Moringa oleifera leaf were given to Groups III and IV respectively as all the treatments were administered daily for four weeks. The activities of superoxide dismutase, catalase, Alanine transaminase, Aspartate transaminase, Alanine phosphatase; glutathione, malondialdehyde, Triglyceride, total Cholesterol and HDL-Cholesterol were determined from spleen homogenate. The results obtained indicated that potassium bromate solution caused substantive oxidative stress leading to spleen injury. However, 20% and 40% aqueous extracts of Moringa oleifera leaf were able to protect against the damage in the spleen of rats in concentration dependent fashion.